Homemade saline doesn’t have preservatives, so it’s like that leftover guacamole—good for a day or two in the fridge. After 24 hours, toss it. Label it with a piece of tape if you’re organized; otherwise, sniff it. If it smells like anything other than “vaguely damp,” it’s gone bad. You don’t want to be the person who snorts expired water.
I once kept a batch for a week because I was feeling lazy. Let’s just say my nose staged a protest that involved a lot of sneezing and regret. Fresh is best, my friend. Make only what you need, like you would for a single-serving pancake.