Sprite is loaded with high-fructose corn syrup (or sugar, depending on where you live). Sugar can actually irritate an already upset stomach, especially if you’re dealing with acid reflux or heartburn. Your esophagus does not want a sugary party.
Plus, Sprite has citric acid—the same stuff in lemons and limes. That acid can aggravate indigestion for some people. Imagine pouring lemon juice on a paper cut, except the paper cut is your stomach lining. Ouch.
So, scientifically speaking, Sprite is not your stomach’s best friend. It’s more like that friend who shows up late to the party and eats all the chips. Not helpful.