So, can you cook out E. coli? Yes, absolutely. But you have to do it right. That means a thermometer, clean surfaces, and zero tolerance for guessing. You’re not a grandma with a "feeling" about the roast—you’re a modern human with science on your side.
And to my buddy Dave: please, for the love of all things holy, stop biting into raw hamburgers. Your stomach isn’t a furnace, and I’m tired of hearing your horror stories. Get a thermometer, throw it in the meat, and when it hits 160°F, you can dig in without fear. You can cook it out—but you have to cook it through.